Wednesday 21 November 2012

Regenerative Medicine - Science Fiction Or Fact !



Regenerative medicine is the process of replacing or regenerating human cells, tissues or organs to restore or establish structures and functions absent or lost due to congenital defects, ageing, disease or damage. Due to  advancement in medical science, it is possible to understand the human genome (a full set of chromosomes, all the inheritable traits of an organism.), thus using body's own mechanisms to heal itself.

The obvious question arises here that how to do that. This is all possible due to the stem cells. Stems cells have the ability to divide and create an identical copy of themselves. This process can continue if necessary till the formation of fully functioning tissue types such as liver, lungs or skin. This replicating nature is called self-renewal. 


The FDA (U S Food and Drug Administration) defines cell therapy as, “The prevention, treatment, cure or mitigation of disease or injuries in humans by the administration of autologous, allogeneic or xenogeneic cells that have been manipulated or altered ex vivo.” taken from Pall Corporation .

The goal of cell therapy, overlapping with that of regenerative medicine, is to repair, replace or restore damaged tissues or organs.

Cell therapy may take the form of a stem cell transplant such as a hematopoietic cell transplant that is used to restore the blood and immune system of patients with leukemia, lymphoma or other blood disorders.

But the term stem self itself represents the basic three types of cells 
1. The Totipotent stem cells
2. The Adult stem cells
3. The Pluripotent Stem cells

The Totipotent stem cells are known as the “master” cells of the body because they have the capacity to differentiate into the 216 specialized cell types that comprise the human body plus the placenta. A fertilized egg is an example of a totipotent cell.

The Adult stem cells are thought to exist in most of the body’s tissues such as the blood, brain, liver, intestine or skin. These cells are committed to becoming cells from their tissue of origin, but they still have the broad ability to become any one of these cells.  
Like stem cells of the bone marrow, for example, can give rise to any of the red or white cells of the blood system. Stem cells in the brain can form all the neurons and support cells of the brain, but can’t form non-brain tissues.

The Pluripotent stem cells are either embryonic or induced Pluripotent stem (iPS) cells. Embryonic stem cells exist only at the earliest stages of embryonic development and go on to form all the cells of the adult body. In humans, these cells no longer exist after about five days after conception. Embryonic stem cells are pluripotent, meaning they have the ability to differentiate into any of the 200 plus cell types required by the body except the fetus.


The induced Pluripotent stem (iPS) cell is taken from any tissue from a child or adult that has been genetically modified to behave like an embryonic stem cell. As the name implies, these cells are pluripotent, which means that they have the ability to form all adult cell types.

The sole aim of Wake Forest Institute for Regenerative Medicine  is to apply the principles of regenerative medicine to repair or replace diseased tissues and organs.
Dr.Anthony Atala, is director of the Institute and his team have been able to produce the first lab-grown organs, a bladder, the artificial urinary bladder to be implanted into a human. 

They have also been able to harvest stem cells from the amniotic fluid of pregnant women. These stems cells are pluripotent, meaning they can be manipulated to differentiate into various types of mature cells that make up nerve, muscle, bone, and other tissues while avoiding the problems of tumor formation.  



But the possible applications of Regenerative Medicine are unlimited. The California Institute for Regenerative Medicines developing new stem cell-based therapies for chronic, debilitating diseases. Diseases like 


Alzheimer's disease
Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)
Arterial disease of the limbs
Autism
Cancer: Glioma
Cancer: Leukemia
Cancer: Melanoma
Cancer: Solid tumor
Deafness
Diabetes
Epidermolysis bullosa
Heart disease
HIV/AIDS
Huntington's disease
Macular degeneration
Multiple sclerosis
Osteoporosis
Parkinson's disease
Severe Combined Immune Deficiency (SCID or "bubble boy disease")
Sickle cell disease
Spinal cord injury
Stroke
Thalassemia ect.

Regenerative Medical Services Pvt. Ltd. is a leading Biotechnology in India company focusing in enhancing the quality of life using advanced cartilage and bone cell treatment. 


RMS Regrow has undertaken over 350 successful bone and cartilage implants, and over 4,000 cord blood samples have been stored. Our company is currently focusing its expertise in stem cell-based therapies such as autologous cartilage regeneration therapy, autologous bone regeneration therapy (ABI-Ossron), umbilical cord blood banking (babycell) and theraform skin reconstruction says Dr Satyen Sanghavi, CSO, Regenerative Medical Services (RMS Regrow).

Some of the other institutes are
Regenerative Medicine Institute(REMEDI) 
Nichi-In Center for Regenerative Medecine

There are a number of organisations like these that are currently focusing on how to make this technology more and more effective.

Nobody knows what secrets the future holds for us.

8 comments:

  1. Read carefully, it's said that Huntington disease has no cure, yes with the western medication but not with herbal medicine, my daughter's situation made me to realize that with doctor Bharat herbal medicine it can be cured. In 2014 she experienced difficulty in concentrating, memory lapses and depression, at first I taught it was stressed from her place of work until I took her to hospital and the doctor made me to understand that it's juvenile Huntington disease because she is still in her late 20s, which she inherited from my late husband that died of the same disease, the doctor told me it has no cure, but gave her some medicine which I noticed that it has side effects, my daughter situation got worst each day that passes, she was the best at her place of work, now a shadow of her self because of this deadly disease, she speaks to herself often, she was really going insane, I do not want to lose my daughter the same way I lost her father, in 2018 I carried out research on internet and bumped into a comment of a lady that got cured of Huntington disease, without wasting time I contacted doctor Bharat whose name was mentioned in the comment, now is been 3 years my daughter is living her best life again, for those that have the disease or have any love one suffering from Huntington disease, contact doctor Bharat via dr.bharatkings@gmail.com

    ReplyDelete
  2. Does anyone still doubt natural herbs? I have seen the great importance of natural herbs and the wonderful work they have done in people's lives. I wonder why people still spend their money on English medicine when natural herbs can cure all kinds of mental diseases. I have seen it with my own eyes. My dad and aunt were cured from Huntington disease with Dr Bharet herbal medicine. He used BUJA herbal medicine to cure my dad and aunt from Huntington disease, I know it is hard to believe but am a living testimony. My dad was diagnosed with Huntington's disease in 2016, we have made use of all western medication yet no improvement and his doctors said there is no cure yet but still carrying out research, my dad experienced depression, anxiety and memory lapses that made him hallucinate always, he speaks to himself often and that made me shed tears each night that passes by. 2019 I searched through the internet for a solution and i came across a comment on a blog written by [Robert Jane] saying she was cured of Huntington disease that she suffered from for 8years. Without wasting time I quickly contacted Dr Bharat whose name was mentioned in the comment Via his email. He asked me questions which I answered correctly he sent his herbal medicine to us here in Ireland through DHL, in less than one month I started seeing positive improvement on my Dad's health so I introduced the medication to my aunt as well, is been 4 years now, my dad and aunt are living their best life again. Though i gave the medication as i was instructed. My dad and aunt are Huntington disease negative after the medication, Huntington disease is completely gone from my family lineage. With Bharat herbal medicine called BUJA Huntington patients can smile again. For those with Huntington disease or having their love ones diagnosed with Huntington's disease contact Dr Bharat now via dr.bharatkings@gmail.com you will come back to testify

    ReplyDelete
  3. Does anyone still doubt natural herbs? I have seen the great importance of natural herbs and the wonderful work they have done in people's lives. I wonder why people still spend their money on English medicine when natural herbs can cure all kinds of mental diseases. I have seen it with my own eyes. My dad and aunt were cured from Huntington disease with Dr Bharet herbal medicine. He used BUJA herbal medicine to cure my dad and aunt from Huntington disease, I know it is hard to believe but am a living testimony. My dad was diagnosed with Huntington's disease in 2016, we have made use of all western medication yet no improvement and his doctors said there is no cure yet but still carrying out research, my dad experienced depression, anxiety and memory lapses that made him hallucinate always, he speaks to himself often and that made me shed tears each night that passes by. 2019 I searched through the internet for a solution and i came across a comment on a blog written by [Robert Jane] saying she was cured of Huntington disease that she suffered from for 8years. Without wasting time I quickly contacted Dr Bharat whose name was mentioned in the comment Via his email. He asked me questions which I answered correctly he sent his herbal medicine to us here in Ireland through DHL, in less than one month I started seeing positive improvement on my Dad's health so I introduced the medication to my aunt as well, is been 4 years now, my dad and aunt are living their best life again. Though i gave the medication as i was instructed. My dad and aunt are Huntington disease negative after the medication, Huntington disease is completely gone from my family lineage. With Bharat herbal medicine called BUJA Huntington patients can smile again. For those with Huntington disease or having their love ones diagnosed with Huntington's disease contact Dr Bharat now via dr.bharatkings@gmail.com you will come back to testify

    ReplyDelete
  4. I want to make this testimony public and as a sign of gratitude to Dr Bharat. On how he saved my husband from Huntington's disease with his herbal medicine called BUJA, i decided to reach out to those still suffering from this disease.
    My husband suffered Huntington disease and it was really tough and heartbreaking for me because he was all i have and the symptoms were terrible, my husband experience hallucination, depression, anxiety, abnormality walking, involuntary movement and memory impairment. We tried various therapies prescribed by our neurologist but none could cure him instead the situation got worsen each day that passes by. I spent much money yet no improvement, I really do not want my husband to die so i searched for a cure on the internet and i bumped into a testimony of (Ronda Jasil) who got cured from Huntington's disease. and she left the e-mail address of the Herbal doctor who has the cure of Huntington disease. I never imagined Huntington's disease has a cure until i contacted him and he assured me my husband will be fine. I got the herbal medication he recommended and my husband used it and in one month we started seeing improvement, now is been 1year and 6 months my husband is okay and full of life again. Huntington's disease has a cure and it is a herbal medicine called BUJA. contact doctor Bharat now on dr.bharatkings@gmail.com Thanks for reading my testimony

    ReplyDelete
  5. Hi everyone, this is good news, a perfect and greats one. My daughter of
    38years who has suffered of Huntington's disease for 2 and half years has been
    cure by a Herbal doctor called Dr Bharat who uses herbal and traditional
    medicine to cure people. I have spent so much money on my daughter's health for
    years but no improvement. A friend told me about this herbal man who cure
    people with herbal medicine. he cures all mental sickness, diseases, viruses, and
    infections with his different herbal curing medicine.The result that
    declares my daughter healed was from a hospital here in USA, And the
    results of the test says my daughter was okay. Dr Bharat said my daughter will be heal in 8weeks(2 months) if she uses the medicine as directed. And
    In 2 weeks i started seeing great improvement, exactly 8weeks we went to confirm from the central hospital and several test that
    was done says my daughter is Huntington's disease negative. She got cured with Dr Bharat herbal medicine, this is super amazing. My daughter is fully okay and back to her work again. I can boldly say that Huntington's disease is 100% curable with doctor Bharat herbal medicine, is real, anyone with Huntington's disease or have love ones that is suffering from Huntington's disease should contact doctor bharat now on his mail. dr.bharatkings@gmail.com

    ReplyDelete
  6. My sister had severe Muscle problems, abnormal eye movements, Difficulty with the physical production of speech, memory lapses. she was placed on tranquilizers 3 times daily, it helped her but not very much. Her neurologist advised us to try natural treatments and introduced me to Natural Organic Herbs, {Huntington disease Herbal formula}, I visited his blogs and read a lot of positive reviews from other patients who used the treatment and made my orders. We immediately started on the treatment for my sister. she had great improvement and relief with this treatment, total decline of symptoms. All her symptoms left and she has been reserved from Huntington Disease. Great improvement with speech, co-ordination, balance, muscle, mood etc, I gained back my life with this herbal treatment and can never be thankful enough. Visit Natural Organic Herbs, reach him directly via {dr.bharatkings@gmail.com}. She's now living like a normal person without any symptoms of Huntington Disease. All thanks to Dr. Bharat

    ReplyDelete
  7. Read carefully, it's said that Huntington disease has no cure, yes with the western medication but not with herbal medicine, my daughter's situation made me to realize that with doctor Bharat herbal medicine it can be cured.. In 2014 she experienced difficulty in concentrating, memory lapses and depression, at first I thought it was stressed from her place of work until I took her to hospital and the doctor made me to understand that it's juvenile Huntington disease because she is still in her late 20s, which she inherited from my late husband that died of the same disease, the doctor told me it has no cure, but gave her some medicine which I noticed that it has side effects, my daughter situation got worst each day that passes, she was the best at her place of work, now a shadow of her self because of this deadly disease, she speaks to herself often, she was really going insane, I do not want to lose my daughter the same way I lost her father, in 2018 I carried out research on internet and bumped into a comment of a lady that got cured of Huntington disease, without wasting time I contacted doctor Bharat whose name was mentioned in the comment, now is been 3 years my daughter is living her best life again, for those that have the disease or have any love one suffering from Huntington disease, contact doctor Bharat via dr.bharatkings@gmail.com

    ReplyDelete
  8. Make me a promise Phyna, my mother said. "Promise me you won't put me in a home or make me live with one of your sisters". It was a joke at the time when my mom was just starting to forget things. 07/10/2020 was the hardest day of my life. Watching my mom talk to herself, packing her things 4-5 times a day, saying she has to go home. It was heartbreaking. I broke down and cried with her a few times and then I realized how hard it must be on my dad too. He can't leave the house, he has to convince her that she lives in their house. I came to the decision to quit my job. My dad needs help. I live 6 hours away but instead of visiting my parents, I'll be visiting my husband. My mom has always been there for me and been my best friend so I want to be there for her. I keep telling myself that I can snap her out of it. I got her numerous medications including RISPERDAL(RISPERIDONE), HALDOL(HALOPPERIDOL), THORAZINE(CHLORPROMAZINE) and TETRABENAZINE(XENAZINE) and DEUTETRABENAZINE (AUSTEDO) instead of helping her, they almost destroyed her due to the side effects. As I was reading more about Huntington's Disease on the internet, I met with some comments of people testifying about Dr. Bharat and his BUJAA HERBAL SUPPLEMENTS that it works for Huntington's. I contacted the doctor immediately and explained my mother's condition to him, he assured me that my mom will be fine and her memory will come back to normal. I ordered his Herbal Supplements and it was delivered to me here in Canada by DHL courier company in less than a week with instructions on how to use them attached in the package. After 3 weeks of using these herbs, we began to see improvement, after 6 months my mom was better, and it's been 2 years now and my mom is completely free from this horrible disease called huntington's. In case your loved one is suffering from huntington's disease I will advise you to use BUJAA HERBAL SUPPLEMENTS it may also help you. You can contact Dr. Bharat via email; dr.bharatkings@gmail.com or Whatsapp him on: +393509392854

    ReplyDelete